By 6am on Friday 22 May, around 400 miles of roadworks will be removed or suspended.
Furthermore, because of planned industrial action on the rail network, they will not be reinstated until 6am, Thursday 28 May.
By lifting 155 sets of roadworks currently operating, 96.9% of the 9.534 miles of major road across England will be free from roadworks.
Director of customer operations at Highways England, Simon Sheldon-Wilson, said: “We will be doing everything possible to manage traffic.
“We’ll have extra traffic offer patrols and recovery vehicles on standby, and we’ll keep customers informed with real-time travel information online and via variable message signs.
“Motorways and major routes are likely to be even busier than usual if the planned industrial action goes ahead,” he added.
“We anticipate that customers may start noticing a difference in traffic during Friday afternoon and evening.”
The government agency did add that, for safety purposes, roadworks will remain at 63 locations – and it’s created a map showing where they’ll be left in place.